MED1 anticorps

N° du produit ABIN272236

Détail du produit anti-MED1 anticorps

Antigène: MED1 (Mediator Complex Subunit 1 (MED1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of TRAP220 protein. (region surrounding Pro697)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MED1

Antigène: MED1 (Mediator Complex Subunit 1 (MED1))

Autre désignation: MED1 (MED1 Produits)

Synonymes: anticorps CRSP1, anticorps CRSP200, anticorps DRIP205, anticorps DRIP230, anticorps PBP, anticorps PPARBP, anticorps PPARGBP, anticorps RB18A, anticorps TRAP220, anticorps TRIP2, anticorps CRSP-1, anticorps MED1, anticorps pbp, anticorps nbr1, anticorps crsp1, anticorps rb18a, anticorps trip2, anticorps pparbp, anticorps crsp200, anticorps drip205, anticorps drip230, anticorps ppargbp, anticorps trap220, anticorps CG7162, anticorps Dmel\\CG7162, anticorps Med1, anticorps Med1/SOP3/TRAP220, anticorps Trap220, anticorps dTRAP220, anticorps AI480703, anticorps CRSP210, anticorps Pparbp, anticorps l11Jus15, anticorps RGD1559552, anticorps mediator complex subunit 1, anticorps calcitonin-related polypeptide beta, anticorps Mediator complex subunit 1, anticorps mediator of RNA polymerase II transcription subunit 1, anticorps MED1, anticorps CALCB, anticorps med1, anticorps Med1

Sujet: In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signaling between transcriptional activators and initiation factors. These complexes include the thyroid hormone receptor-associated protein (TRAP) complex, which interacts with thyroid receptors (TR), vitamin D receptors and other steroid receptors to facilitate hormone induced transcriptional activation. The TRAP complex consists of numerous proteins ranging in size from 20 to 240 kDa, including TRAP95, TRAP100, TRAP150, TRAP220 and TRAP230, that are characterized by the presence of a nuclear receptor recognition motif which mediates the liganddependent binding of TRAP proteins to the nuclear receptors. TRAP220 and TRAP100 are widely expressed and most abundantly detected in skeletal muscle, heart and placenta. TRAP95, TRAP150 and TRAP230 facilitate TR induced transcription by associating with an additional transcriptional coactivating complex SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes.Synonyms: ARC205, Activator-recruited cofactor 205 kDa component, CRSP1, CRSP200, DRIP205, DRIP230, Mediator complex subunit 1, PBP, PPARBP, PPARGBP, Peroxisome proliferator-activated receptor-binding protein, RB18A, TRAP220, TRIP2, Thyroid hormone receptor-associated protein complex 220 kDa component, Thyroid receptor-interacting protein 2, Vitamin D receptor-interacting protein complex component DRIP205, p53 regulatory protein RB18A

Poids moléculaire: approx. 170 kDa

ID gène: 5469

NCBI Accession: NP_004765

UniProt: Q15648

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha