ACTN3 anticorps

N° du produit ABIN272284

Détail du produit anti-ACTN3 anticorps

Antigène: ACTN3 (Actinin, alpha 3 (ACTN3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACTN3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous levels of Actinin-α3 protein. (region surrounding Glu25)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Pureté: > 95 % pure by SDS-PAGE

Information d'application

Indications d'application: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: DO NOT FREEZE!

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur ACTN3

Antigène: ACTN3 (Actinin, alpha 3 (ACTN3))

Autre désignation: alpha-Actinin-3 / ACTN3 (ACTN3 Produits)

Synonymes: anticorps CG8953, anticorps Dmel\\CG8953, anticorps ORF1, anticorps acta-3, anticorps dabp, anticorps ACTN2, anticorps actn3, anticorps actnl, anticorps zgc:63559, anticorps fb95c03, anticorps wu:fb95c03, anticorps wu:fc11d03, anticorps zgc:77243, anticorps actinin alpha 3 (gene/pseudogene), anticorps actinin alpha 3, anticorps alpha actinin 3, anticorps actinin alpha 3a, anticorps actinin alpha 3 (gene/pseudogene) L homeolog, anticorps alpha-actinin-3, anticorps actinin alpha 3b, anticorps ACTN3, anticorps Actn3, anticorps actn3a, anticorps actn3.L, anticorps actn3, anticorps LOC100439754, anticorps actn3b

Sujet: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.Synonyms: Alpha actinin skeletal muscle isoform 3, F-actin cross-linking protein

Poids moléculaire: approx. 103 kDa

ID gène: 89

NCBI Accession: NP_001095

UniProt: Q08043

Pathways: Cell-Cell Junction Organization