LIM Domain Kinase 1 anticorps

N° du produit ABIN2724737

Détail du produit anti-LIM Domain Kinase 1 anticorps

Antigène: LIM Domain Kinase 1 (LIMK1)

Reactivité: Humain, Souris, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LIM Domain Kinase 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Attributs du produit: Homo sapiens LIM domain kinase 1 (LIMK1), transcript variant 1

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human LIMK1(NP_002305) produced in HEK293T cell.

Clone: 3H6

Isotype: IgG2b

Information d'application

Indications d'application: WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100,

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-LIM Domain Kinase 1 (ABIN2724737)

Yang, He, Zhang, Chen, Kong, Xie, Jia, Liu, Zhou: "Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain." dans: Neuropharmacology, Vol. 125, pp. 284-294, (2018) (PubMed).

Détails sur LIM Domain Kinase 1

Antigène: LIM Domain Kinase 1 (LIMK1)

Autre désignation: LIMK1 (LIMK1 Produits)

Synonymes: anticorps limk1, anticorps xlimk1, anticorps GB16654, anticorps LIMK1, anticorps LIMK, anticorps LIMK-1, anticorps LIM domain kinase 1, anticorps LIM domain kinase 1a, anticorps LIM domain kinase 1 L homeolog, anticorps LIM-domain containing, protein kinase, anticorps LIMK1, anticorps limk1a, anticorps limk1, anticorps CpipJ_CPIJ000717, anticorps LOC413152, anticorps Limk1, anticorps limk1.L

Sujet: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Poids moléculaire: 72.4 kDa

ID gène: 3984

NCBI Accession: NM_002314

HGNC: 3984

Pathways: Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events