LIM Domain Kinase 1 anticorps
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- Antigène Voir toutes LIM Domain Kinase 1 (LIMK1) Anticorps
- LIM Domain Kinase 1 (LIMK1)
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Reactivité
- Humain, Souris, Rat, Singe
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp LIM Domain Kinase 1 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
- Attributs du produit
- Homo sapiens LIM domain kinase 1 (LIMK1), transcript variant 1
- Purification
- Purified from mouse ascites fluids by affinity chromatography
- Immunogène
- Full length human recombinant protein of human LIMK1(NP_002305) produced in HEK293T cell.
- Clone
- 3H6
- Isotype
- IgG2b
- Top Product
- Discover our top product LIMK1 Anticorps primaire
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- Indications d'application
- WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100,
- Commentaires
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The concentration of the product may vary between diferrent lots.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5-1.0 mg/mL
- Buffer
- PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
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Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain." dans: Neuropharmacology, Vol. 125, pp. 284-294, (2018) (PubMed).
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Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain." dans: Neuropharmacology, Vol. 125, pp. 284-294, (2018) (PubMed).
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- Antigène
- LIM Domain Kinase 1 (LIMK1)
- Autre désignation
- LIMK1 (LIMK1 Produits)
- Synonymes
- anticorps limk1, anticorps xlimk1, anticorps GB16654, anticorps LIMK1, anticorps LIMK, anticorps LIMK-1, anticorps LIM domain kinase 1, anticorps LIM domain kinase 1a, anticorps LIM domain kinase 1 L homeolog, anticorps LIM-domain containing, protein kinase, anticorps LIMK1, anticorps limk1a, anticorps limk1, anticorps CpipJ_CPIJ000717, anticorps LOC413152, anticorps Limk1, anticorps limk1.L
- Sujet
- There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Poids moléculaire
- 72.4 kDa
- ID gène
- 3984
- NCBI Accession
- NM_002314
- HGNC
- 3984
- Pathways
- Caspase Cascade in Apoptosis, Regulation of Cell Size, CXCR4-mediated Signaling Events
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