PDE10A anticorps

N° du produit ABIN2728473

L’anticorps anti-PDE10A Monoclonal Souris est utilisé pour la détection de PDE10A dans des échantillons de Humain. Il a été validé pour WB et FACS.

Aperçu rapide pour PDE10A anticorps (ABIN2728473)

Antigène: PDE10A (phosphodiesterase 10A (PDE10A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDE10A est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 4A10

Détail du produit anti-PDE10A anticorps

Attributs du produit: Homo sapiens phosphodiesterase 10A (PDE10A), transcript variant 2

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogène: Full length human recombinant protein of human PDE10A (NP_006652) produced in HEK293T cell.

Isotype: IgG1

Information d'application

Indications d'application: WB:1:500, FC:1:50

Commentaires:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS ( pH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur PDE10A

Antigène: PDE10A (phosphodiesterase 10A (PDE10A))

Autre désignation: PDE10A

Sujet: Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3'cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. There are 11 subtypes of PDEs, named PDE1-11, PDE4, 7 and 8 selectively degrade cAMP, PDE5, 6 and 9 selectively degrade cGMP and PDE1, 2, 3, 10 and 11 degrade both cyclic nucleotides. PDEs are expressed ubiquitously,with each subtype having a specific tissue distribution. These enzymes are involved in many signal transduction pathways and their functions include vascular smooth muscle proliferation and contraction, cardiac contractility,platelet aggregation, hormone secretion, immune cell activation, and they are involved in learning and memory.

Poids moléculaire: 88.4 kDa

ID gène: 10846

NCBI Accession: NM_006661

HGNC: 10846

Pathways: cAMP Metabolic Process