Cet anticorps anti-Podoplanin Monoclonal Souris (Clone 18H5) (ABIN2745556) détecte spécifiquement Podoplanin dans WB, IHC et FACS.
L’anticorps est réactif avec des échantillons de Humain.
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL.
Concentration
Lot specific
Buffer
Lyophilized.
Stock
4 °C,-20 °C
Stockage commentaire
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.
Date de péremption
6 months
Antigène
Podoplanin (PDPN)
Autre désignation
Podoplanin
Sujet
Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma and brain tumors. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of podoplanin. Through its association with CLEC-2, podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth.