TEK anticorps (Extracellular Domain)

N° du produit ABIN2745570

L’anticorps Souris Monoclonal anti-TEK a été validé pour WB, ELISA et FACS. Il convient pour détecter TEK dans des échantillons de Humain.

Aperçu rapide pour TEK anticorps (Extracellular Domain) (ABIN2745570)

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TEK est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: Tek2

Détail du produit anti-TEK anticorps

Épitope: Extracellular Domain

Specificité: Native human TIE-2 in ELISA experiments and on the surface of different human cell types.

Réactivité croisée: Humain

Purification: Protein G purified.

Immunogène: Recombinant human soluble extracellular domain of TIE-2.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Centrifuge vial prior to opening. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL.

Concentration: Lot specific

Buffer: Lyophilized.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Date de péremption: 6 months

Détails sur TEK

Antigène: TEK (TEK Tyrosine Kinase, Endothelial (TEK))

Autre désignation: TIE-2

Sujet: TIE-2 acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. It has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. It is required for normal angiogenesis and heart development during embryogenesis and for post-natal hematopoiesis. After birth, it activates or inhibits angiogenesis, depending on the context. It inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1 and ultimately to the stimulation of sprouting angiogenesis.

UniProt: Q02763

Pathways: Signalisation RTK, Growth Factor Binding