phosphodiesterase 5A, cGMP-Specific (PDE5A) (AA 825-875), (C-Term) anticorps

Détails pour le produit réf. ABIN2747175
Antigène
  • CGB-PDE
  • CN5A
  • PDE5
  • PDE5A2
  • Cgbpde
  • Cn5n
  • Pde5
  • Pde5a1
  • PDE5A
  • pde5a
  • cgb-pde
  • cn5a
  • pde5
  • pde5a1
  • phosphodiesterase 5A
  • phosphodiesterase 5A, cGMP-specific
  • phosphodiesterase 5A S homeolog
  • phosphodiesterase 5A, cGMP-specific, b
  • PDE5A
  • Pde5a
  • pde5a.S
  • pde5ab
  • pde5a
Épitope
AA 825-875, C-Term
9
3
3
3
2
2
1
1
Reactivité
Poulet, Humain
52
20
18
6
5
4
3
1
1
1
1
Hôte
Lapin
41
8
5
Clonalité
Polyclonal
Conjugué
Inconjugué
4
3
1
1
1
1
1
1
1
Application
Confocal Microscopy (CM), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
40
27
16
14
10
9
6
6
3
2
1
Options
Immunogène Synthetic peptide common to all PDE5A variants taken within amino acid region 825-875 on human PDE5A protein.
Blocking Peptide Blocking peptide for this product available: ABIN2750983
Isotype IgG
Purification Affinity Purified
Antigène
Autre désignation PDE5A (PDE5A Antibody Extrait)
UniProt O76074
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.55-0.60 μg/μL
Produit citée dans: Carøe Nordgaard, Kruse, Gammeltoft, Kruuse: "Role of Ser102 and Ser104 as regulators of cGMP hydrolysis by PDE5A." dans: PLoS ONE, Vol. 9, Issue 9, pp. e107627, 2015 (PubMed).

Rajagopal, Nalli, Kumar, Bhattacharya, Hu, Mahavadi, Grider, Murthy: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." dans: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, 2015 (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." dans: Urology, Vol. 85, Issue 4, pp. 964.e1-6, 2015 (PubMed).

Witting, Kruuse, Nyhuus, Prahm, Citirak, Lundgaard, von Huth, Vejlstrup, Lindberg, Krag, Vissing: "Effect of sildenafil on skeletal and cardiac muscle in Becker muscular dystrophy." dans: Annals of neurology, Vol. 76, Issue 4, pp. 550-7, 2014 (PubMed).

Ückert, Oelke, Albrecht, Breitmeier, Kuczyk, Hedlund: "Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)." dans: International journal of impotence research, Vol. 23, Issue 5, pp. 206-12, 2012 (PubMed).

Ückert, Waldkirch, Sonnenberg, Sandner, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." dans: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, 2012 (PubMed).

Mietens, Tasch, Feuerstacke, Eichner, Volkmann, Schermuly, Grimminger, Müller, Middendorff: "Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not." dans: Molecular and cellular endocrinology, Vol. 349, Issue 2, pp. 145-53, 2012 (PubMed).

Luong, Rey-Perra, Vadivel, Gilmour, Sauve, Koonen, Walker, Todd, Gressens, Kassiri, Nadeem, Morgan, Eaton, Dyck, Archer, Thébaud: "Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia." dans: Circulation, Vol. 123, Issue 19, pp. 2120-31, 2011 (PubMed).

Sasseville, Côté, Gagnon, Richard: "Up-regulation of 3'5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation." dans: Endocrinology, Vol. 149, Issue 11, pp. 5568-76, 2009 (PubMed).

Albrecht, Uckert, Oelke, Andersson, Jonas, Tröger, Hedlund: "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?" dans: Journal of forensic and legal medicine, Vol. 14, Issue 5, pp. 270-4, 2007 (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." dans: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, 2007 (PubMed).

Liu, Xin, Xin, Yuan, Tian, Guo: "Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats." dans: Asian journal of andrology, Vol. 7, Issue 4, pp. 381-8, 2006 (PubMed).

Werkström, Svensson, Andersson, Hedlund: "Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects." dans: BJU international, Vol. 98, Issue 2, pp. 414-23, 2006 (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." dans: Urology, Vol. 65, Issue 3, pp. 604-10, 2005 (PubMed).

Wang, Gang Zhang, Lan Zhang, Chopp: "Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone." dans: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 25, Issue 9, pp. 1150-8, 2005 (PubMed).

Monfort, Muñoz, Felipo: "Chronic hyperammonemia in vivo impairs long-term potentiation in hippocampus by altering activation of cyclic GMP-dependent-protein kinase and of phosphodiesterase 5." dans: Journal of neurochemistry, Vol. 94, Issue 4, pp. 934-42, 2005 (PubMed).

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