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CD70 anticorps (PE)

CD70 Reactivité: Humain FACS Hôte: Souris Monoclonal Ki-24 PE
N° du produit ABIN2749173
  • Antigène Voir toutes CD70 Anticorps
    CD70 (CD70 Molecule (CD70))
    Reactivité
    • 97
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 62
    • 34
    • 8
    • 2
    • 1
    Souris
    Clonalité
    • 63
    • 43
    • 1
    Monoclonal
    Conjugué
    • 51
    • 13
    • 10
    • 10
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD70 est conjugé à/à la PE
    Application
    • 51
    • 47
    • 45
    • 37
    • 26
    • 19
    • 18
    • 11
    • 11
    • 9
    • 8
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The mouse monoclonal antibody Ki-24 recognizes an extracellular epitope of CD70, an approximately 50 kDa type II transmembrane glycoprotein expressed on activated lymphocytes and some B cell leukemias.
    Réactivité croisée (Details)
    Human
    Purification
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    human L428 cell line
    Clone
    Ki-24
    Isotype
    IgG3 kappa
    Top Product
    Discover our top product CD70 Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Commentaires

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Trebing, El-Mesery, Schäfer, Weisenberger, Siegmund, Silence, Wajant: "CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants." dans: Cell death & disease, Vol. 5, pp. e1035, (2014) (PubMed).

    Hashimoto-Okada, Kitawaki, Kadowaki, Iwata, Morimoto, Hori, Uchiyama: "The CD70-CD27 interaction during the stimulation with dendritic cells promotes naive CD4(+) T cells to develop into T cells producing a broad array of immunostimulatory cytokines in humans." dans: International immunology, Vol. 21, Issue 8, pp. 891-904, (2009) (PubMed).

    Kaufmann, Amariglio, Rosenthal, Hirsch, Many, Rechavi: "Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 10, pp. 6940-7, (2005) (PubMed).

    Israel, Pickles, Segal, Gerard, Kenney: "Enhancement of adenovirus vector entry into CD70-positive B-cell Lines by using a bispecific CD70-adenovirus fiber antibody." dans: Journal of virology, Vol. 75, Issue 11, pp. 5215-21, (2001) (PubMed).

  • Antigène
    CD70 (CD70 Molecule (CD70))
    Autre désignation
    CD70 (CD70 Produits)
    Synonymes
    anticorps CD27LG, anticorps Cd27l, anticorps Tnfsf7, anticorps CD27L, anticorps TNFSF7, anticorps CD70 antigen, anticorps CD70 molecule, anticorps Cd70 molecule, anticorps Cd70, anticorps CD70
    Sujet
    CD70 Molecule,CD70, also known as TNFSF7 or CD27L, is a 50 kDa type II transmembrane glycoprotein of the TNF superfamily. It is expressed mainly on activated lymphocytes, including NK cells, and forms trimeric structure. CD70 plays a role in T-cell activation, proliferation and differentiation, in enhancing the generation of cytolytic T cells, and in long-term maintenance of T cell memory. It is also involved in B cell differentiation induced by activated plasmacytoid dendritic cells, which also express CD70.,CD27L, TNFSF7, CD27 ligand, TNLG8A
    ID gène
    970
    UniProt
    P32970
    Pathways
    Cancer Immune Checkpoints
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