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Integrin Alpha2b anticorps

CD41 Reactivité: Souris FACS, ELISA, IHC (fro), IP, IHC (p), Func Hôte: Rat Monoclonal MWReg30 unconjugated
N° du produit ABIN2749191
  • Antigène Voir toutes Integrin Alpha2b (CD41) Anticorps
    Integrin Alpha2b (CD41)
    Reactivité
    • 125
    • 33
    • 21
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 84
    • 43
    • 24
    Rat
    Clonalité
    • 105
    • 40
    • 1
    Monoclonal
    Conjugué
    • 59
    • 17
    • 13
    • 12
    • 6
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Integrin Alpha2b est non-conjugé
    Application
    • 105
    • 48
    • 32
    • 27
    • 21
    • 19
    • 13
    • 13
    • 10
    • 9
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func)
    Specificité
    The rat monoclonal antibody MWReg30 recognizes an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain, 120 kDa) and GPIIb beta (light chain, 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
    Réactivité croisée (Details)
    Mouse
    Purification
    Purified by protein-G affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    niveau d'endotoxine
    Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
    Immunogène
    Murine platelets
    Clone
    MWReg30
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product CD41 Anticorps primaire
  • Indications d'application
    Functional application: Platelet depletion.
    Flow cytometry: Recommended dilution: 1-4 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4
    Agent conservateur
    Azide free
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Ramsey, Zhang, Brown, Steensma, Lin, Wu: "Stress-induced hematopoietic failure in the absence of immediate early response gene X-1 (IEX-1, IER3)." dans: Haematologica, Vol. 99, Issue 2, pp. 282-91, (2014) (PubMed).

    Brancaleone, Gobbetti, Cenac, le Faouder, Colom, Flower, Vergnolle, Nourshargh, Perretti: "A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation." dans: Blood, Vol. 122, Issue 4, pp. 608-17, (2013) (PubMed).

    Boisset, Clapes, Van Der Linden, Dzierzak, Robin: "Integrin αIIb (CD41) plays a role in the maintenance of hematopoietic stem cell activity in the mouse embryonic aorta." dans: Biology open, Vol. 2, Issue 5, pp. 525-32, (2013) (PubMed).

    Sullivan, Wang, Tawfik, Luyendyk: "Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 115, Issue 1, pp. 286-94, (2010) (PubMed).

  • Antigène
    Integrin Alpha2b (CD41)
    Autre désignation
    CD41 (CD41 Produits)
    Synonymes
    anticorps AI172977, anticorps CD41, anticorps CD41B, anticorps GpIIb, anticorps alphaIIb, anticorps BDPLT16, anticorps BDPLT2, anticorps GP2B, anticorps GPIIb, anticorps GT, anticorps GTA, anticorps HPA3, anticorps integrin alpha 2b, anticorps integrin subunit alpha 2b, anticorps Itga2b, anticorps ITGA2B
    Sujet
    Integrin subunit alpha 2b,CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.,Platelet GPIIb, Integrin alpha-IIb, GPalpha IIb, GPIIb
    ID gène
    16399
    UniProt
    Q9QUM0
    Pathways
    Integrin Complex
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