The antibody HIP2 reacts with an extracellular epitope on beta (b) subunit of CD41 glycoprotein (light chain, 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
CD41
Reactivité: Humain
ELISA, IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Flow cytometry: Recommended dilution: 1-4 μg/mL
Restrictions
For Research Use only
Concentration
1 mg/mL
Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Do not freeze.
Stock
4 °C
Stockage commentaire
Store at 2-8°C. Do not freeze.
Wu: "[Production and application of anti-human platelet GP IIb/IIIa monoclonal antibodies]." dans: Zhonghua yi xue za zhi, Vol. 69, Issue 8, pp. 427-30, 30, (1990) (PubMed).
Integrin subunit alpha 2b,CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.,GT, GTA, GP2B, HPA3, GPIIb