Cadherin 5 anticorps

N° du produit ABIN2749192

Cet anticorps anti-Cadherin 5 est un anticorps Souris Monoclonal détectant Cadherin 5 dans WB, IP, FACS, ICC et IHC (fro). Adapté pour Humain. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Cadherin 5 anticorps (ABIN2749192)

Antigène: Cadherin 5 (CDH5)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cadherin 5 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 55-7H1

Détail du produit anti-Cadherin 5 anticorps

Fonction: Anti-Hu CD144 Purified

Specificité: The mouse monoclonal antibody 55-7H1 recognizes a calcium-independent extracellular epitope on CD144 (VE-cadherin, cadherin 5), an adhesion molecule expressed on endothelial cells.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human endothelial cells

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-Cadherin 5 (ABIN2749192)

Hamilton, Foss, Leach: "Establishment of a human in vitro model of the outer blood-retinal barrier." dans: Journal of anatomy, Vol. 211, Issue 6, pp. 707-16, (2007) (PubMed).

Limaye, Li, Hahn, Xia, Berndt, Vadas, Gamble: "Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members." dans: Blood, Vol. 105, Issue 8, pp. 3169-77, (2005) (PubMed).

Détails sur Cadherin 5

Antigène: Cadherin 5 (CDH5)

Autre désignation: CD144

Sujet: Cadherin 5,CD144 / VE-cadherin (cadherin 5) is the major cadherin that is present at endothelial junctions. It is also strictly endothelial specific. Under vascular permeability increasing conditions (and also in capillaries and veins) CD144 is being phosphorylated, which promotes its rapid and reversible internalization. On the contrary, binding of p120 catenin (delta1 catenin) maintains CD144 localization at the plasma membrane, which stabilizes the junction and reduces vascular permeability.,Cadherin 5, CDH5, 7B4, VE-cadherin

ID gène: 1003

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2