DLL4 anticorps

N° du produit ABIN2749212

L’anticorps Souris Monoclonal anti-DLL4 a été validé pour FACS et Func. Il convient pour détecter DLL4 dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour DLL4 anticorps (ABIN2749212)

Antigène: DLL4 (delta-Like 4 (DLL4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DLL4 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func)

Clone: MHD4-46

Détail du produit anti-DLL4 anticorps

Fonction: Anti-DLL4 Purified Low Endotoxin

Specificité: The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

niveau d'endotoxine: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogène: recombinant soluble human DLL4

Isotype: IgG1 kappa

Information d'application

Indications d'application: Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-DLL4 (ABIN2749212)

Sekine, Koyanagi, Koyama, Hozumi, Chiba, Yagita: "Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes." dans: Arthritis research & therapy, Vol. 14, Issue 2, pp. R45, (2012) (PubMed).

Oishi, Sunamura, Egawa, Motoi, Unno, Furukawa, Habib, Yagita: "Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer." dans: Pancreas, Vol. 39, Issue 6, pp. 897-903, (2010) (PubMed).

Yamanda, Ebihara, Asada, Okazaki, Niu, Ebihara, Koyanagi, Yamaguchi, Yagita, Arai: "Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade." dans: Blood, Vol. 113, Issue 15, pp. 3631-9, (2009) (PubMed).

Détails sur DLL4

Antigène: DLL4 (delta-Like 4 (DLL4))

Autre désignation: DLL4

Sujet: Delta like canonical Notch ligand 4,DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.,Delta like ligand 4, AOS6, canonical Notch ligand 4

ID gène: 54567

UniProt: Q9NR61

Pathways: Signalisation Notch