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UBE2D3 anticorps (AA 1-147) (FITC)

UBE2D3 Reactivité: Humain ELISA Hôte: Lapin Polyclonal FITC
N° du produit ABIN2754313
  • Antigène Voir toutes UBE2D3 Anticorps
    UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))
    Épitope
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    AA 1-147
    Reactivité
    • 34
    • 12
    • 11
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 33
    • 2
    Polyclonal
    Conjugué
    • 15
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UBE2D3 est conjugé à/à la FITC
    Application
    • 25
    • 19
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Ubiquitin-conjugating enzyme E2 D3 protein (1-147AA)
    Isotype
    IgG
    Top Product
    Discover our top product UBE2D3 Anticorps primaire
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3 (UBE2D3))
    Autre désignation
    UBE2D3 (UBE2D3 Produits)
    Synonymes
    anticorps E2(17)KB3, anticorps UBC4/5, anticorps UBCH5C, anticorps eff, anticorps fb36f02, anticorps wu:fb36f02, anticorps zgc:56340, anticorps 1100001F19Rik, anticorps 9430029A22Rik, anticorps AA414951, anticorps UBE2D3P, anticorps Xubc4, anticorps e2(17)kb3, anticorps ubc4/5, anticorps ubch5c, anticorps ube2d3.1, anticorps ube2d2, anticorps xubc4, anticorps wu:fj13d01, anticorps zgc:73200, anticorps ubiquitin conjugating enzyme E2 D3, anticorps ubiquitin-conjugating enzyme E2D 3, anticorps ubiquitin conjugating enzyme E2 D3 L homeolog, anticorps ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like, anticorps UBE2D3, anticorps ube2d3, anticorps Ube2d3, anticorps LOC100223566, anticorps ube2d3.L, anticorps ube2d2l
    Sujet

    Background: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes \'Lys-11\'-, as well as\'Lys-48\'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions \'Lys-21 and/or \'Lys-22\' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction (By similarity).

    Aliases: E2(17)KB3 antibody, MGC43926 antibody, MGC5416 antibody, PRO2116 antibody, UB2D3_HUMAN antibody, UBC 4/5 antibody, UBC4/5 antibody, UBC4/5 homolog yeast antibody, UBC4/5, S. cerevisiae, homolog of antibody, UBCH 5C antibody, UBCH5C antibody, Ube2d3 antibody, Ubiquitin carrier protein antibody, Ubiquitin carrier protein D3 antibody, Ubiquitin conjugating enzyme E2 17 kDa 3 antibody, Ubiquitin conjugating enzyme E2 D3 antibody, Ubiquitin conjugating enzyme E2D 3 (homologous to yeast UBC4/5) antibody, Ubiquitin conjugating enzyme E2D 3 (UBC4/5 homolog yeast) antibody, Ubiquitin conjugating enzyme E2D 3 antibody, Ubiquitin protein ligase D3 antibody, Ubiquitin-conjugating enzyme E2 D3 antibody, Ubiquitin-conjugating enzyme E2(17)KB 3 antibody, Ubiquitin-conjugating enzyme E2-17 kDa 3 antibody, Ubiquitin-protein ligase D3 antibody

    UniProt
    P61077
    Pathways
    Activation of Innate immune Response, Toll-Like Receptors Cascades
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