hCoV-OC43 Spike anticorps (AA 15-344)

N° du produit ABIN2754654

Cet anticorps Lapin Polyclonal détecte spécifiquement hCoV-OC43 Spike dans ELISA, IF et WB. Il présente une réactivité envers Human Coronavirus OC43 (HCoV-OC43) et a été mentionné dans 3+ publications.

Aperçu rapide pour hCoV-OC43 Spike anticorps (AA 15-344) (ABIN2754654)

Antigène: hCoV-OC43 Spike (HCoV-OC43 S) (Coronavirus OC43 Spike Protein (HCoV-OC43 S))

Reactivité: Human Coronavirus OC43 (HCoV-OC43)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp hCoV-OC43 Spike est non-conjugé

Application: ELISA, Immunofluorescence (IF), Western Blotting (WB)

Détail du produit anti-hCoV-OC43 Spike anticorps

Épitope: AA 15-344

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogène: Recombinant Human coronavirus OC43 Spike glycoprotein protein(15-344aa)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C/-80 °C

Références pour anticorps anti-hCoV-OC43 Spike (ABIN2754654)

Kim, Jeong, Yu, Shin, Ku, Cha, Han, Hong, Kim, Kim, Woo, Bae: "Efficient Human Cell Coexpression System and Its Application to the Production of Multiple Coronavirus Antigens." dans: Advanced biology, Vol. 5, Issue 4, pp. e2000154, (2021) (PubMed).

Wang, Li, Zhou, Wiltse, Zand: "Antibody Mediated Immunity to SARS-CoV-2 and Human Coronaviruses: Multiplex Beads Assay and Volumetric Absorptive Microsampling to Generate Immune Repertoire Cartography." dans: Frontiers in immunology, Vol. 12, pp. 696370, (2021) (PubMed).

Min, Kim, Jin, Kwon: "Kurarinone Inhibits HCoV-OC43 Infection by Impairing the Virus-Induced Autophagic Flux in MRC-5 Human Lung Cells." dans: Journal of clinical medicine, Vol. 9, Issue 7, (2020) (PubMed).

Détails sur hCoV-OC43 Spike

Antigène: hCoV-OC43 Spike (HCoV-OC43 S) (Coronavirus OC43 Spike Protein (HCoV-OC43 S))

Autre désignation: OC43 Spike Glycoprotein

Classe de substances: Viral Protein

Sujet: S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

UniProt: P36334