PINK1 anticorps (N-Term)

N° du produit ABIN2764090

Cet anticorps Lapin Polyclonal détecte spécifiquement PINK1 dans WB, IHC et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour PINK1 anticorps (N-Term) (ABIN2764090)

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Enzyme Immunoassay (EIA)

Détail du produit anti-PINK1 anticorps

Épitope: N-Term

Réactivité croisée: Humain

Attributs du produit: PTEN-induced putative kinase protein 1,Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

Purification: Antigen Immunoaffiinity Purification

Immunogène: Synthetic peptide derived from the N-terminal of the human PINK1 protein.

Isotype: IgG

Information d'application

Indications d'application: Antibody can be used for immunohistochemical staining (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur PINK1

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Autre désignation: PINK1

UniProt: Q9BXM7

Pathways: Autophagy