PINK1 anticorps (E417G)

N° du produit ABIN2764094

L’anticorps anti-PINK1 Polyclonal Lapin est utilisé pour la détection de PINK1 dans des échantillons de Humain. Il a été validé pour WB, IHC et EIA.

Aperçu rapide pour PINK1 anticorps (E417G) (ABIN2764094)

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PINK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Enzyme Immunoassay (EIA)

Détail du produit anti-PINK1 anticorps

Épitope: E417G

Réactivité croisée: Humain

Attributs du produit: PTEN-induced putative kinase protein 1,Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

Purification: Antigen Immunoaffiinity Purification

Immunogène: Synthetic peptide derived from a mutant form of the human PINK1 protein

Isotype: IgG

Information d'application

Indications d'application: Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur PINK1

Antigène: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Autre désignation: PINK1

UniProt: Q9BXM7

Pathways: Autophagy