BHMT anticorps (N-Term)

N° du produit ABIN2773785

L’anticorps Lapin Polyclonal anti-BHMT a été validé pour WB et IHC. Il convient pour détecter BHMT dans des échantillons de Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin et Poisson zèbre (Danio rerio). Il y a 3+ publications disponibles.

Aperçu rapide pour BHMT anticorps (N-Term) (ABIN2773785)

Antigène: BHMT (Betaine--Homocysteine S-Methyltransferase (BHMT))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BHMT est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-BHMT anticorps

Épitope: N-Term

Séquence: AVEHPEAVRQ LHREFLRAGS NVMQTFTFYA SEDKLENRGN YVLEKISGQE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against BHMT. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BHMT

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 406 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-BHMT (ABIN2773785)

Jiang, Hurt, Breen, Stabler, Allen, Orlicky, Maclean: "Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap." dans: Biology open, Vol. 4, Issue 9, pp. 1154-62, (2015) (PubMed).

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." dans: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Maclean, Jiang, Greiner, Allen, Stabler et al.: "Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine ..." dans: Molecular genetics and metabolism, Vol. 105, Issue 3, pp. 395-403, (2012) (PubMed).

Détails sur BHMT

Antigène: BHMT (Betaine--Homocysteine S-Methyltransferase (BHMT))

Autre désignation: BHMT

Sujet: BHMT is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in its gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.Betaine-homocysteine methyltransferase is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in BHMT could lead to hyperhomocyst(e)inemia,but such a defect has not yet been observed.
Alias Symbols: BHMT1
Protein Interaction Partner: BHMT, BBS4, BBS2, BBS1, ALG9, LAMTOR3,
Protein Size: 406

Poids moléculaire: 45 kDa

ID gène: 635

NCBI Accession: NM_001713, NP_001704

UniProt: Q93088

Pathways: Methionine Biosynthetic Process