PRP19 anticorps (Middle Region)

N° du produit ABIN2773819

Cet anticorps Lapin Polyclonal détecte spécifiquement PRP19 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Poisson zèbre (Danio rerio) et Cobaye et a été mentionné dans 1 publication.

Aperçu rapide pour PRP19 anticorps (Middle Region) (ABIN2773819)

Antigène: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Poisson zèbre (Danio rerio), Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRP19 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PRP19 anticorps

Épitope: Middle Region

Séquence: PSVVGAGEPM DLGELVGMTP EIIQKLQDKA TVLTTERKKR GKTVPEELVK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PRPF19. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PRPF19

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 504 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PRP19 (ABIN2773819)

Song, Cui, Zhong, Han: "Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium." dans: Journal of clinical pathology, Vol. 62, Issue 9, pp. 802-7, (2009) (PubMed).

Détails sur PRP19

Antigène: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Autre désignation: PRPF19

Sujet: PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM].
Alias Symbols: NMP200, PRP19, PSO4, UBOX4, hPSO4, SNEV
Protein Interaction Partner: HUWE1, USP4, UBE2D3, SUMO2, CEP76, CEP250, TUBGCP3, CEP57, VCP, UBC, SUMO1, NEDD8, LIN28A, EXOC7, EXOC3, RPA3, RPA2, RPA1, RNF2, SUZ12, EED, rev, MEPCE, SEC13, PARK2, TARDBP, UBD, CSNK2A2, UCHL5, WHSC1, U2AF1, PRCC, HSP90AA1, HSPB1, FN1, RBM10, vif, CDC40
Protein Size: 504

Poids moléculaire: 55 kDa

ID gène: 27339

NCBI Accession: NM_014502, NP_055317

UniProt: Q9UMS4

Pathways: Ribonucleoprotein Complex Subunit Organization