HSD11B1 anticorps (N-Term)

N° du produit ABIN2773867

Il existe 2+ publications pour ce produit. L’anticorps anti-HSD11B1 Polyclonal Lapin est utilisé pour la détection de HSD11B1 dans des échantillons de Humain, Rat, Souris, Chien, Lapin, Mouton, Boeuf (Vache), Cobaye et Cheval. Il a été validé pour WB et IHC.

Aperçu rapide pour HSD11B1 anticorps (N-Term) (ABIN2773867)

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Reactivité: Humain, Rat, Souris, Chien, Lapin, Mouton, Boeuf (Vache), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSD11B1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HSD11B1 anticorps

Épitope: N-Term

Fonction: HSD11B1 Antibody - N-terminal region

Séquence: QKVVSHCLEL GAASAHYIAG TMEDMTFAEQ FVAQAGKLMG GLDMLILNHI

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 93%

Attributs du produit: This is a rabbit polyclonal antibody against HSD11B1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HSD11B1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45714-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HSD11B1 (ABIN2773867)

Kuroda, Venkatakrishnan, Salker, Lucas, Shaheen, Kuroda, Blanks, Christian, Quenby, Brosens: "Induction of 11?-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells." dans: Molecular endocrinology (Baltimore, Md.), Vol. 27, Issue 2, pp. 192-202, (2013) (PubMed).

Lei, Chen, Georgiou, Sooranna, Khanjani, Brosens, Bennett, Johnson: "Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1?-induced COX-2 expression in human term myometrial cells." dans: PLoS ONE, Vol. 7, Issue 11, pp. e50167, (2012) (PubMed).

Détails sur HSD11B1

Antigène: HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))

Autre désignation: HSD11B1

Sujet:

Background Information: HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.

Gene Name: Hydroxysteroid (11-beta) dehydrogenase 1

Alternative Symbols: HDL, 11-DH, HSD11, HSD11B, HSD11L, CORTRD2, SDR26C1, 11-beta-HSD1

Protein Name: Corticosteroid 11-beta-dehydrogenase isozyme 1

Poids moléculaire: 32kDa

ID gène: 3290

NCBI Accession: NP_005516

UniProt: P28845

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Carbohydrate Metabolic Process