FZR1 anticorps (N-Term)

N° du produit ABIN2773984

L’anticorps Lapin Polyclonal anti-FZR1 a été validé pour WB. Il convient pour détecter FZR1 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio) et Porc.

Aperçu rapide pour FZR1 anticorps (N-Term) (ABIN2773984)

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FZR1 anticorps

Épitope: N-Term

Séquence: RQIIIQNENT VPCVSEMRRT LTPANSPVSS PSKHGDRFIP SRAGANWSVN

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against Fzr1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 493 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur FZR1

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Autre désignation: Fzr1

Sujet: Fzr1 is the key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Fzr1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: AW108046, Cdh1, FZR, FZR2, Fyr, HCDH, HCDH1
Protein Interaction Partner: Arhgap35, Rrm2, Ccnb1, Cdc27, Sirt2, Smurf1, Skil, Ube2c, Csf3r,
Protein Size: 493

Poids moléculaire: 55 kDa

ID gène: 56371

NCBI Accession: NM_019757, NP_062731

UniProt: Q9R1K5

Pathways: DNA Replication, Synthesis of DNA