FZR1 anticorps (N-Term)

N° du produit ABIN2773984

Détail du produit anti-FZR1 anticorps

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Poisson zèbre (Danio rerio), Chien, Cobaye, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZR1 est non-conjugé

Application: Western Blotting (WB)

Séquence: RQIIIQNENT VPCVSEMRRT LTPANSPVSS PSKHGDRFIP SRAGANWSVN

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against Fzr1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide corresponding to a region of Mouse

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 493 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur FZR1

Antigène: FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))

Autre désignation: Fzr1 (FZR1 Produits)

Synonymes: anticorps CDH1-C, anticorps FYR, anticorps FZR, anticorps CDH1, anticorps fzr1, anticorps CDC20C, anticorps FZR2, anticorps HCDH, anticorps HCDH1, anticorps AW108046, anticorps Cdh1, anticorps Fyr, anticorps zgc:55450, anticorps fizzy and cell division cycle 20 related 1, anticorps fizzy/cell division cycle 20 related 1, anticorps fizzy-related protein homolog, anticorps fizzy/cell division cycle 20 related 1 (Drosophila), anticorps fizzy/cell division cycle 20 related 1a, anticorps Fzr1, anticorps CDH1-C, anticorps FZR1, anticorps LOC100027495, anticorps LOC100179951, anticorps fzr1a

Sujet: Fzr1 is the key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Fzr1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
Alias Symbols: AW108046, Cdh1, FZR, FZR2, Fyr, HCDH, HCDH1
Protein Interaction Partner: Arhgap35, Rrm2, Ccnb1, Cdc27, Sirt2, Smurf1, Skil, Ube2c, Csf3r,
Protein Size: 493

Poids moléculaire: 55 kDa

ID gène: 56371

NCBI Accession: NM_019757, NP_062731

UniProt: Q9R1K5

Pathways: DNA Replication, Synthesis of DNA