ZCCHC11 anticorps (Middle Region)

N° du produit ABIN2774235

Cet anticorps anti-ZCCHC11 est un anticorps Lapin Polyclonal détectant ZCCHC11 dans WB. Adapté pour Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval et Lapin.

Aperçu rapide pour ZCCHC11 anticorps (Middle Region) (ABIN2774235)

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZCCHC11 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ZCCHC11 anticorps

Épitope: Middle Region

Séquence: GSAQQQGDQS IRTRQSSECS ESPSYSPQPQ PFPQNSSQSA AITQPSSQPG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ZCCHC11. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ZCCHC11

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1645 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ZCCHC11

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Autre désignation: ZCCHC11

Sujet: ZCCHC11 is the uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mRNA degradation.
Alias Symbols: PAPD3, TUT4
Protein Interaction Partner: UBC, MYC, TIFA, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL4B, CUL5, ELAVL1,
Protein Size: 1645

Poids moléculaire: 185 kDa

ID gène: 23318

NCBI Accession: NM_001009881, NP_001009881

UniProt: Q5TAX3

Pathways: Stem Cell Maintenance