ZCCHC11 anticorps (C-Term)

N° du produit ABIN6242704

Détail du produit anti-ZCCHC11 anticorps

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Épitope: AA 1568-1600, C-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZCCHC11 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This (Mouse) Zcchc11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1568-1600 amino acids from the C-terminal region of (Mouse) Zcchc11.

Clone: RB51164

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur ZCCHC11

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Autre désignation: Zcchc11 (ZCCHC11 Produits)

Synonymes: anticorps PAPD3, anticorps TUT4, anticorps ZCCHC11, anticorps DKFZp459G145, anticorps 6030404K05Rik, anticorps 9230115F04Rik, anticorps PPAPD3, anticorps mKIAA0191, anticorps wu:fc06h08, anticorps wu:fy37g11, anticorps papd3, anticorps zinc finger CCHC-type containing 11, anticorps zinc finger, CCHC domain containing 11, anticorps zinc finger CCHC domain containing 11, anticorps ZCCHC11, anticorps Zcchc11, anticorps zcchc11

Sujet: Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre- let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B (By similarity). Also catalyzes the 3' uridylation of miR- 26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation (By similarity).

Poids moléculaire: 184650

UniProt: B2RX14

Pathways: Stem Cell Maintenance