ZCCHC11 anticorps (Middle Region)

N° du produit ABIN2774235

Détail du produit anti-ZCCHC11 anticorps

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZCCHC11 est non-conjugé

Application: Western Blotting (WB)

Séquence: GSAQQQGDQS IRTRQSSECS ESPSYSPQPQ PFPQNSSQSA AITQPSSQPG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 92%, Human: 100%, Mouse: 92%, Rabbit: 92%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ZCCHC11. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ZCCHC11

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1645 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ZCCHC11

Antigène: ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))

Autre désignation: ZCCHC11 (ZCCHC11 Produits)

Synonymes: anticorps PAPD3, anticorps TUT4, anticorps ZCCHC11, anticorps DKFZp459G145, anticorps 6030404K05Rik, anticorps 9230115F04Rik, anticorps PPAPD3, anticorps mKIAA0191, anticorps wu:fc06h08, anticorps wu:fy37g11, anticorps papd3, anticorps zinc finger CCHC-type containing 11, anticorps zinc finger, CCHC domain containing 11, anticorps zinc finger CCHC domain containing 11, anticorps ZCCHC11, anticorps Zcchc11, anticorps zcchc11

Sujet: ZCCHC11 is the uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mRNA degradation.
Alias Symbols: PAPD3, TUT4
Protein Interaction Partner: UBC, MYC, TIFA, CAND1, DCUN1D1, COPS5, CUL1, CUL2, CUL4B, CUL5, ELAVL1,
Protein Size: 1645

Poids moléculaire: 185 kDa

ID gène: 23318

NCBI Accession: NM_001009881, NP_001009881

UniProt: Q5TAX3

Pathways: Stem Cell Maintenance