SH2D1A anticorps (Middle Region)

N° du produit ABIN2774285

Cet anticorps Lapin Polyclonal détecte spécifiquement SH2D1A dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Porc, Cheval, Lapin, Chien et Poisson zèbre (Danio rerio).

Aperçu rapide pour SH2D1A anticorps (Middle Region) (ABIN2774285)

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Cheval, Lapin, Chien, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH2D1A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SH2D1A anticorps

Épitope: Middle Region

Séquence: YTYRVSQTET GSWSAETAPG VHKRYFRKIK NLISAFQKPD QGIVIPLQYP

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%

Attributs du produit: This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human SH2D1A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SH2D1A

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Autre désignation: SH2D1A

Sujet: SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Protein Interaction Partner: LHX4, TNK2, UBC, LYN, MAPK11, MAPK1, ERBB3, EGFR, MAPK14, CD244, ELAVL1, SLAMF7, SLAMF6, ARHGEF7, CD84, SLAMF1, DOK1, FYB, LY9, ARHGEF6, LCK, FYN, GRB2,
Protein Size: 125

Poids moléculaire: 13 kDa

ID gène: 4068

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process