LGMN anticorps (Middle Region)

N° du produit ABIN2774455

L’anticorps Lapin Polyclonal anti-LGMN a été validé pour WB. Il convient pour détecter LGMN dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval, Poisson zèbre (Danio rerio), Mouton et Porc.

Aperçu rapide pour LGMN anticorps (Middle Region) (ABIN2774455)

Antigène: LGMN (Legumain (LGMN))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Cobaye, Cheval, Poisson zèbre (Danio rerio), Mouton, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LGMN est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LGMN anticorps

Épitope: Middle Region

Séquence: ESSYACYYDE KRSTYLGDWY SVNWMEDSDV EDLTKETLHK QYHLVKSHTN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 79%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 86%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against LGMN. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human LGMN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 433 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur LGMN

Antigène: LGMN (Legumain (LGMN))

Autre désignation: LGMN

Sujet: This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined.
Alias Symbols: AEP, LGMN1, PRSC1
Protein Interaction Partner: USP17L2, TRAF6, USP17L9P, SUMO1, UBC, NEDD8, LAMC3, ACIN1, IGF2BP3, HNRNPR, FBXO6, ISG15, LGMN,
Protein Size: 433

Poids moléculaire: 48 kDa

ID gène: 5641

NCBI Accession: NM_005606, NP_005597

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades