HERC5 anticorps (Middle Region)

N° du produit ABIN2774739

Cet anticorps Lapin Polyclonal détecte spécifiquement HERC5 dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Boeuf (Vache), Cheval, Lapin, Porc et Rat.

Aperçu rapide pour HERC5 anticorps (Middle Region) (ABIN2774739)

Antigène: HERC5 (Hect Domain and RLD 5 (HERC5))

Reactivité: Humain, Boeuf (Vache), Cheval, Lapin, Porc, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HERC5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HERC5 anticorps

Épitope: Middle Region

Séquence: FHPEELKDVI VGNTDYDWKT FEKNARYEPG YNSSHPTIVM FWKAFHKLTL

Homologie: Cow: 79%, Horse: 79%, Human: 100%, Pig: 79%, Rabbit: 86%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against HERC5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human HERC5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1024 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HERC5

Antigène: HERC5 (Hect Domain and RLD 5 (HERC5))

Autre désignation: HERC5

Sujet: HERC5 is a member of the HERC family of ubiquitin ligases.It contains a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulates expression of HERC5 protein in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets.This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
Alias Symbols: CEB1, CEBP1
Protein Interaction Partner: UBC, SMAD4, UBE2D1, gag, ISG15, TXNRD1, IRF3, HSPA8, CTNNB1, HERC5, SIRT7, STK38, PITX2, ERCC2, CCND1, CCNE1, CCNB1, CCNA2, NME2, CDKN1A,
Protein Size: 1024

Poids moléculaire: 117 kDa

ID gène: 51191

NCBI Accession: NM_016323, NP_057407

UniProt: Q69G20