CHRNA7 anticorps (C-Term)

N° du produit ABIN2774850

Cet anticorps anti-CHRNA7 Polyclonal Lapin (ABIN2774850) détecte spécifiquement CHRNA7 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Cobaye et Lapin.

Aperçu rapide pour CHRNA7 anticorps (C-Term) (ABIN2774850)

Antigène: CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHRNA7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CHRNA7 anticorps

Épitope: C-Term

Fonction: CHRNA7 Antibody - C-terminal region

Séquence: GQPPEGDPDL AKILEEVRYI ANRFRCQDES EAVCSEWKFA ACVVDRLCLM

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 77%, Rabbit: 93%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CHRNA7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of human CHRNA7

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36595-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur CHRNA7

Antigène: CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))

Autre désignation: CHRNA7

Sujet:

Background Information: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Gene Name: cholinergic receptor nicotinic alpha 7 subunit

Alternative Symbols: NACHRA7, CHRNA7-2

Protein Name: neuronal acetylcholine receptor subunit alpha-7

Poids moléculaire: 55kDa

ID gène: 1139

NCBI Accession: NP_000737

UniProt: P36544

Pathways: Synaptic Membrane