CHRNA7 anticorps (AA 52-259)

N° du produit ABIN5611363

Détail du produit anti-CHRNA7 anticorps

Antigène: CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))

Épitope: AA 52-259

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CHRNA7 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS), Neutralization (Neut)

Purification: purified

Immunogène: Purified recombinant fragment of human CHRNA7 (AA: extra 52-259) expressed in E. coli.

Clone: 7F10G1

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-CHRNA7 (ABIN5611363)

Bychkov, Kirichenko, Mikhaylova, Paramonov, Kirpichnikov, Shulepko, Lyukmanova: "Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes." dans: Acta naturae, Vol. 14, Issue 3, pp. 95-99, (2022) (PubMed).

Bychkov, Shulepko, Shlepova, Kulbatskii, Chulina, Paramonov, Baidakova, Azev, Koshelev, Kirpichnikov, Shenkarev, Lyukmanova: "SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer." dans: Frontiers in cell and developmental biology, Vol. 9, pp. 739391, (2021) (PubMed).

Kulbatskii, Shenkarev, Bychkov, Loktyushov, Shulepko, Koshelev, Povarov, Popov, Peigneur, Chugunov, Kozlov, Sharonova, Efremov, Skrebitsky, Tytgat, Kirpichnikov, Lyukmanova: "Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain." dans: Frontiers in cell and developmental biology, Vol. 9, pp. 662227, (2021) (PubMed).

Détails sur CHRNA7

Antigène: CHRNA7 (Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))

Autre désignation: CHRNA7 (CHRNA7 Produits)

Synonymes: anticorps CHRNA7-2, anticorps NACHRA7, anticorps dZ70B1.1, anticorps Acra7, anticorps alpha7, anticorps BTX, anticorps NARAD, anticorps nAChRa7, anticorps CHRNA7, anticorps cholinergic receptor nicotinic alpha 7 subunit, anticorps neuronal acetylcholine receptor subunit alpha-7, anticorps cholinergic receptor, nicotinic, alpha 7 (neuronal), anticorps cholinergic receptor, nicotinic, alpha polypeptide 7, anticorps cholinergic receptor, nicotinic, alpha 7, anticorps CHRNA7, anticorps LOC100374356, anticorps chrna7, anticorps Chrna7, anticorps LOC100060521

Sujet:

Description: The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

Aliases: NACHRA7, CHRNA7-2

Poids moléculaire: 56.4 kDa

ID gène: 1139

HGNC: 1139

Pathways: Synaptic Membrane