MCM3 anticorps (C-Term)

N° du produit ABIN2774880

Cet anticorps Lapin Polyclonal détecte spécifiquement MCM3 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Cobaye, Lapin et Chien.

Aperçu rapide pour MCM3 anticorps (C-Term) (ABIN2774880)

Antigène: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Reactivité: Humain, Souris, Rat, Cheval, Porc, Boeuf (Vache), Cobaye, Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MCM3 anticorps

Épitope: C-Term

Séquence: SQEDQEQKRK RRKTRQPDAK DGDSYDPYDF SDTEEEMPQV HTPKTADSQE

Homologie: Cow: 92%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MCM3. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human MCM3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 808 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MCM3

Antigène: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Autre désignation: MCM3

Sujet: MCM3 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Alias Symbols: HCC5, MGC1157, P1-MCM3, P1.h, RLFB
Protein Interaction Partner: SUMO2, MCMBP, UBC, KEAP1, MDM2, MCM6, MCM5, ACTBL2, MGEA5, CAP1, SAE1, HSP90B1, TPM3, HSP90AA1, FKBP5, FKBP4, MIB1, YWHAQ, UBD, TCEA1, MCM10, ORC5, ORC4, MCM2, ITGA4, FN1, CSNK2A1, CDK2, CDC6, CDC5L, PNKP, CDC7, VCAM1, NOTCH1, POLD1, POLA1, MCM7, PIPSL, P
Protein Size: 808

Poids moléculaire: 89 kDa

ID gène: 4172

NCBI Accession: NM_002388, NP_002379

UniProt: P25205

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA