MCM7 anticorps (Middle Region)

N° du produit ABIN2774887

Détail du produit anti-MCM7 anticorps

Antigène: MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))

Épitope: Middle Region

Reactivité: Humain, Rat, Lapin, Cobaye, Boeuf (Vache), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: HRIVKMNKSE DDESGAGELT REELRQIAEE DFYEKLAASI APEIYGHEDV

Homologie: Cow: 92%, Guinea Pig: 85%, Horse: 92%, Human: 100%, Rabbit: 92%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against MCM7. It was validated on Western Blot and immunohistochemistry.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MCM7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 719 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MCM7

Antigène: MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))

Autre désignation: MCM7 (MCM7 Produits)

Synonymes: anticorps CDC47, anticorps MCM2, anticorps P1.1-MCM3, anticorps P1CDC47, anticorps P85MCM, anticorps PNAS146, anticorps MCM7, anticorps AI747533, anticorps Mcmd7, anticorps mCDC47, anticorps chunp6911, anticorps nyz175, anticorps sr:nyz175, anticorps cdc47, anticorps cdc47-2, anticorps mcm7, anticorps xmcm7, anticorps CG4978, anticorps DmMCM7, anticorps DmeMCM7, anticorps Dmel\\CG4978, anticorps McM7, anticorps Mcp-PCR1, anticorps PCR1, anticorps anon-EST:Liang-1.66, anticorps clone 1.66, anticorps minichromosome maintenance complex component 7, anticorps mini-chromosome maintenance complex protein 7, anticorps minichromosome maintenance complex component 2, anticorps minichromosome maintenance complex component 7 L homeolog, anticorps Minichromosome maintenance 7, anticorps minichromosome maintenance complex component 7 S homeolog, anticorps MCM complex subunit Mcm7, anticorps MCM7, anticorps CDC47, anticorps Mcm7, anticorps MCM2, anticorps mcm7, anticorps mcm7.L, anticorps mcm7.S

Sujet: MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: MCM2, CDC47, P85MCM, P1CDC47, PNAS146, P1.1-MCM3
Protein Interaction Partner: AK8, MIPOL1, C8orf34, USHBP1, MCMBP, CCDC102B, TRIM54, MBIP, UBQLN1, TRIM27, NAB2, KIFC3, GOLGA2, PNMA1, UBC, SP2, HAUS2, CEP250, CEP57, SUMO2, SUMO3, PCNA, STAU1, SUZ12, RNF2, MCM4, MCM2, HSP90AB1, PRMT1, PRRC1, CLUH, TOMM34, TRIM16, HYOU1, BAG3, MIB1, P
Protein Size: 719

Poids moléculaire: 81 kDa

ID gène: 4176

NCBI Accession: NM_005916, NP_005907

UniProt: P33993

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA