DMBT1 anticorps (N-Term)

N° du produit ABIN2775367

L’anticorps anti-DMBT1 Polyclonal Lapin est utilisé pour la détection de DMBT1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour DMBT1 anticorps (N-Term) (ABIN2775367)

Antigène: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMBT1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DMBT1 anticorps

Épitope: N-Term

Fonction: DMBT1 Antibody - N-terminal region

Séquence: SWSTPSPDTL PTITLPASTV GSESSLALRL VNGGDRCQGR VEVLYRGSWG

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against DMBT1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DMBT1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42352-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur DMBT1

Antigène: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Autre désignation: DMBT1

Sujet:

Background Information: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.

Gene Name: Deleted in malignant brain tumors 1

Alternative Symbols: SAG, GP340, SALSA, muclin

Protein Name: Deleted in malignant brain tumors 1 protein

Poids moléculaire: 258kDa

ID gène: 1755

NCBI Accession: NP_015568

UniProt: Q9UGM3

Pathways: Activation of Innate immune Response