EIF2AK1 anticorps (N-Term)

N° du produit ABIN2775397

Détail du produit anti-EIF2AK1 anticorps

Antigène: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF2AK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: TCSDEFSSLR LHHNRAITHL MRSAKERVRQ DPCEDISRIQ KIRSREVALE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against EIF2AK1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human EIF2AK1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 630 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EIF2AK1

Antigène: EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))

Autre désignation: EIF2AK1 (EIF2AK1 Produits)

Synonymes: anticorps HCR, anticorps Hri, anticorps HRI, anticorps wu:fj97h09, anticorps zgc:153232, anticorps eukaryotic translation initiation factor 2 alpha kinase 1, anticorps eukaryotic translation initiation factor 2-alpha kinase 1, anticorps eukaryotic translation initiation factor 2 alpha kinase 1 L homeolog, anticorps EIF2AK1, anticorps eif2ak1, anticorps Eif2ak1, anticorps eif2ak1.L

Sujet: EIF2AK1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. Sequence Note: The sequence AF181071.1 is a chimeric mRNA clone. Only the heme-regulated initiation factor 2-alpha kinase region was propagated into this RefSeq record.
Alias Symbols: HRI, KIAA1369, HCR
Protein Interaction Partner: MDM2, UBC, HSP90AA1, LIG4, CDC37, EIF2AK1, EIF2S1,
Protein Size: 630

Poids moléculaire: 71 kDa

ID gène: 27102

NCBI Accession: NM_014413, NP_055228

UniProt: Q9BQI3

Pathways: Hepatitis C