MFN2 anticorps (C-Term)

N° du produit ABIN2775408

Cet anticorps anti-MFN2 est un anticorps Lapin Polyclonal détectant MFN2 dans WB et IHC. Adapté pour Humain, Rat, Souris, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval et Poisson zèbre (Danio rerio). Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour MFN2 anticorps (C-Term) (ABIN2775408)

Antigène: MFN2 (Mitofusin 2 (MFN2))

Reactivité: Humain, Rat, Souris, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MFN2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MFN2 anticorps

Épitope: C-Term

Séquence: LEQEIAAMNK KIEVLDSLQS KAKLLRNKAG WLDSELNMFT HQYLQPSR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against MFN2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human MFN2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 757 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MFN2 (ABIN2775408)

Siu, Zhou, Yu, Zhang, Wang, Liang, Chen, Chan, Yu: "Hepatitis C virus NS5A protein cooperates with phosphatidylinositol 4-kinase IIIα to induce mitochondrial fragmentation." dans: Scientific reports, Vol. 6, pp. 23464, (2016) (PubMed).

Détails sur MFN2

Antigène: MFN2 (Mitofusin 2 (MFN2))

Autre désignation: MFN2

Sujet: MFN2 is a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. It is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke.This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
Alias Symbols: CMT2A, CMT2A2, CPRP1, HSG, KIAA0214, MARF
Protein Interaction Partner: UBC, MARCH5, PARK2, UBE2N, MFN2, TER94, MAVS, vpr, HUWE1, MAPK9,
Protein Size: 757

Poids moléculaire: 86 kDa

ID gène: 9927

NCBI Accession: NM_014874, NP_055689

UniProt: O95140

Pathways: Skeletal Muscle Fiber Development