Caldesmon anticorps (C-Term)

N° du produit ABIN2775537

Cet anticorps anti-Caldesmon est un anticorps Lapin Polyclonal détectant Caldesmon dans WB et IHC. Adapté pour Humain, Rat, Souris, Chien, Lapin, Boeuf (Vache), Cheval, Cobaye, Saccharomyces cerevisiae et Poisson zèbre (Danio rerio).

Aperçu rapide pour Caldesmon anticorps (C-Term) (ABIN2775537)

Antigène: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Reactivité: Humain, Rat, Souris, Chien, Lapin, Boeuf (Vache), Cheval, Cobaye, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caldesmon est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Caldesmon anticorps

Épitope: C-Term

Séquence: VLEEEEQRRK QEEADRKLRE EEEKRRLKEE IERRRAEAAE KRQKMPEDGL

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 85%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against CALD1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human CALD1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 793 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Caldesmon

Antigène: Caldesmon (CALD1) (Caldesmon 1 (CALD1))

Autre désignation: CALD1

Sujet: CALD1 is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction.This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Alias Symbols: CDM, H-CAD, L-CAD, MGC21352, NAG22, HCAD, LCAD
Protein Interaction Partner: TP53, RPA3, RPA2, RPA1, PHAX, FH, EPB41L2, CSNK2A1, LRCH3, PRKACA, PAN2, UBC, HSP90AA1, CALM1, ACTN1, TINF2, POT1, ISG15, TERF1, ARRB1, Poc1b, Cep76, Sass6, Pafah1b1, TERF2, SHC1, CDK1, CALM3, GRB2,
Protein Size: 793

Poids moléculaire: 93 kDa

ID gène: 800

NCBI Accession: NM_033138, NP_149129

UniProt: Q05682

Pathways: Myometrial Relaxation and Contraction