ube3a anticorps (N-Term)

N° du produit ABIN2775647

Cet anticorps Lapin Polyclonal détecte spécifiquement ube3a dans WB. Il présente une réactivité envers Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Boeuf (Vache), Saccharomyces cerevisiae et Chévre.

Aperçu rapide pour ube3a anticorps (N-Term) (ABIN2775647)

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Reactivité: Humain, Souris, Rat, Lapin, Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Boeuf (Vache), Saccharomyces cerevisiae, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ube3a est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ube3a anticorps

Épitope: N-Term

Séquence: SLQAKDEDKD EDEKEKAACS AAAMEEDSEA SSSRIGDSSQ GDNNLQKLGP

Homologie: Cow: 93%, Dog: 93%, Goat: 90%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%, Yeast: 91%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against UBE3A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human UBE3A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 875 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ube3a

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Autre désignation: UBE3A

Sujet: UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Alias Symbols: ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Protein Interaction Partner: KLHL38, UBE2D1, UBB, TP53, TAT, AFG3L1P, ATG9A, ASAP3, AHSP, UBE3A, UBC, MEOX2, MAGEA8, JADE1, YOD1, UBE2L3, UBE2D3, PSMD14, SHFM1, ARNTL, LPP, HSF1, DR1, BTF3L4, LRSAM1, P3H1, NPLOC4, IPO11, DBNL, LSM1, ARPC1B, METTL1, SACS, ARC, RAD23A, PTPN3, CEBPA, SC
Protein Size: 875

Poids moléculaire: 101 kDa

ID gène: 7337

NCBI Accession: NM_000462, NP_000453

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway