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HSBP1 anticorps (N-Term)

HSBP1 Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Lapin, Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776380
  • Antigène Voir toutes HSBP1 Anticorps
    HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))
    Épitope
    • 8
    • 5
    • 1
    N-Term
    Reactivité
    • 27
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat, Porc, Boeuf (Vache), Lapin, Chien, Poisson zèbre (Danio rerio), Cheval, Cobaye
    Hôte
    • 24
    • 2
    • 1
    Lapin
    Clonalité
    • 25
    • 2
    Polyclonal
    Conjugué
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp HSBP1 est non-conjugé
    Application
    • 11
    • 11
    • 10
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Séquence
    AETDPKTVQD LTSVVQTLLQ QMQDKFQTMS DQIIGRIDDM SSRIDDLEKN
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 79%, Pig: 100%, Rabbit: 100%, Rat: 93%, Zebrafish: 86%
    Attributs du produit
    This is a rabbit polyclonal antibody against HSBP1. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human HSBP1
    Top Product
    Discover our top product HSBP1 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 76 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tai, McFall, Huang, Demeler, Fox, Brubaker, Radhakrishnan, Morimoto: "Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain." dans: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 735-45, (2002) (PubMed).

  • Antigène
    HSBP1 (Heat Shock Factor Binding Protein 1 (HSBP1))
    Autre désignation
    HSBP1 (HSBP1 Produits)
    Synonymes
    anticorps HSBP1, anticorps npc-a-13, anticorps NPC-A-13, anticorps hsbp1, anticorps hsbp1a, anticorps 0610007A03Rik, anticorps AA408769, anticorps Hsp25, anticorps zgc:73224, anticorps heat shock factor binding protein 1 like 1, anticorps heat shock factor binding protein 1, anticorps Heat shock factor binding protein 1, anticorps heat shock factor binding protein 1 S homeolog, anticorps heat shock factor binding protein 1 L homeolog, anticorps heat shock factor binding protein 1b, anticorps HSBP1L1, anticorps HSBP1, anticorps Bm1_07370, anticorps hsbp1.S, anticorps hsbp1, anticorps hsbp1.L, anticorps Hsbp1, anticorps hsbp1b
    Sujet
    The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response.
    Alias Symbols: DKFZp686D1664, DKFZp686O24200, NPC-A-13
    Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-7, LNX1, KIAA1217, CCHCR1, CCDC53, SDCBP, KIFC3, HSBP1, UBC, VCP, RRBP1, RB1CC1, HSF1, HSPA1A, HSPA4,
    Protein Size: 76
    Poids moléculaire
    8 kDa
    ID gène
    3281
    NCBI Accession
    NM_001537, NP_001528
    UniProt
    O75506
    Pathways
    SARS-CoV-2 Protein Interactome
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