FZD7 anticorps (C-Term)

N° du produit ABIN2776708

Détail du produit anti-FZD7 anticorps

Antigène: FZD7 (Frizzled Family Receptor 7 (FZD7))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Lapin, Porc, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD7 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: PDFTVFMIKY LMTMIVGITT GFWIWSGKTL QSWRRFYHRL SHSSKGETAV

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Yeast: 82%

Attributs du produit: This is a rabbit polyclonal antibody against FZD7. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human FZD7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 574 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FZD7 (ABIN2776708)

McIver, Stanger, Santarelli, Roman, Nixon, McLaughlin: "A unique combination of male germ cell miRNAs coordinates gonocyte differentiation." dans: PLoS ONE, Vol. 7, Issue 4, pp. e35553, (2012) (PubMed).

Schmuck, Warneke, Behrens, Simon, Weichert, Röcken: "Genotypic and phenotypic characterization of side population of gastric cancer cell lines." dans: The American journal of pathology, Vol. 178, Issue 4, pp. 1792-804, (2011) (PubMed).

Gökmen-Polar, Toroni, Hocevar, Badve, Zhao, Shen, Bruckheimer, Kinch, Miller: "Dual targeting of EphA2 and ER restores tamoxifen sensitivity in ER/EphA2-positive breast cancer." dans: Breast cancer research and treatment, Vol. 127, Issue 2, pp. 375-84, (2011) (PubMed).

Ohba, Lanigan, Roessler: "Leptin receptor JAK2/STAT3 signaling modulates expression of Frizzled receptors in articular chondrocytes." dans: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 18, Issue 12, pp. 1620-9, (2010) (PubMed).

Ueno, Hiura, Suehiro, Hazama, Hirata, Oka, Imai, Dahiya, Hinoda: "Frizzled-7 as a potential therapeutic target in colorectal cancer." dans: Neoplasia (New York, N.Y.), Vol. 10, Issue 7, pp. 697-705, (2008) (PubMed).

Détails sur FZD7

Antigène: FZD7 (Frizzled Family Receptor 7 (FZD7))

Autre désignation: FZD7 (FZD7 Produits)

Synonymes: anticorps FzE3, anticorps Fz-7, anticorps Xfz7, anticorps frizzled-7, anticorps frizzled7, anticorps frz-7, anticorps frz7, anticorps fz7, anticorps fzd7-a, anticorps fzd7-b, anticorps fze3, anticorps Fz7, anticorps cFz-7, anticorps fb38g02, anticorps fc44b09, anticorps fz13, anticorps fz7a, anticorps fz7b, anticorps wu:fb38g02, anticorps wu:fc44b09, anticorps zg13, anticorps frizzled class receptor 7, anticorps frizzled class receptor 7 L homeolog, anticorps frizzled class receptor 7b, anticorps FZD7, anticorps fzd7.L, anticorps fzd7, anticorps Fzd7, anticorps fzd7b

Sujet: FZD7 is 7-transmembrane domain protein that is receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
Alias Symbols: FzE3
Protein Interaction Partner: UBC, UBQLN4, MAGI3, UBQLN1, DLG2, DLG4, DLG1,
Protein Size: 574

Poids moléculaire: 63 kDa

ID gène: 8324

NCBI Accession: NM_003507, NP_003498

UniProt: O75084

Pathways: Signalisation WNT, Stem Cell Maintenance