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FZD9 anticorps (N-Term)

FZD9 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Cobaye, Poisson zèbre (Danio rerio) WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2776709
  • Antigène Voir toutes FZD9 Anticorps
    FZD9 (Frizzled Family Receptor 9 (FZD9))
    Épitope
    • 16
    • 14
    • 7
    • 7
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 77
    • 30
    • 21
    • 10
    • 9
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Cobaye, Poisson zèbre (Danio rerio)
    Hôte
    • 76
    • 1
    Lapin
    Clonalité
    • 77
    Polyclonal
    Conjugué
    • 37
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FZD9 est non-conjugé
    Application
    • 52
    • 37
    • 13
    • 12
    • 12
    • 9
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Séquence
    RPPGDLGPGA GGSGTCENPE KFQYVEKSRS CAPRCGPGVE VFWSRRDKDF
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 92%, Rat: 93%, Zebrafish: 100%
    Attributs du produit
    This is a rabbit polyclonal antibody against FZD9. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human FZD9
    Top Product
    Discover our top product FZD9 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 591 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Tennis, Van Scoyk, Heasley, Vandervest, Weiser-Evans, Freeman, Keith, Simpson, Nemenoff, Winn: "Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1." dans: Neoplasia (New York, N.Y.), Vol. 12, Issue 3, pp. 244-53, (2010) (PubMed).

  • Antigène
    FZD9 (Frizzled Family Receptor 9 (FZD9))
    Autre désignation
    FZD9 (FZD9 Produits)
    Synonymes
    anticorps CD349, anticorps FZD3, anticorps mfz9, anticorps Fz-9, anticorps cFz-9, anticorps fz11, anticorps fzd9, anticorps fzx, anticorps hm:zehl0603, anticorps zehl0603, anticorps zg11, anticorps frizzled class receptor 9, anticorps frizzled class receptor 9a, anticorps frizzled class receptor 9b, anticorps FZD9, anticorps Fzd9, anticorps fzd9a, anticorps fzd9b
    Sujet
    FZD9 contains 1 FZ (frizzled) domain and belongs to the G-protein coupled receptor Fz/Smo family. It is receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members. It may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney.
    Alias Symbols: FZD3, CD349
    Protein Interaction Partner: KRTAP10-3, SIAH1, MDFI, WNT7A, WNT1, WNT2,
    Protein Size: 591
    Poids moléculaire
    65 kDa
    ID gène
    8326
    NCBI Accession
    NM_003508, NP_003499
    UniProt
    O00144
    Pathways
    Signalisation WNT
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