MSH2 anticorps (N-Term)

N° du produit ABIN2776761

Cité dans 1 publication. Cet anticorps anti-MSH2 Polyclonal Lapin (ABIN2776761) détecte spécifiquement MSH2 dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Cobaye, Poisson zèbre (Danio rerio), Boeuf (Vache), Cheval et Lapin.

Aperçu rapide pour MSH2 anticorps (N-Term) (ABIN2776761)

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Poisson zèbre (Danio rerio), Boeuf (Vache), Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MSH2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MSH2 anticorps

Épitope: N-Term

Fonction: MSH2 Antibody - N-terminal region

Séquence: GNKASKENDW YLAYKASPGN LSQFEDILFG NNDMSASIGV VGVKMSAVDG

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against MSH2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MSH2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41351-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-MSH2 (ABIN2776761)

Wedrén, Lovmar, Humphreys, Magnusson, Melhus, Syvänen, Kindmark, Landegren, Fermér, Stiger, Persson, Baron, Weiderpass: "Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study." dans: BMC cancer, Vol. 8, pp. 322, (2009) (PubMed).

Détails sur MSH2

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Autre désignation: MSH2

Sujet:

Background Information: MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Alternative Symbols: FCC1, COCA1, HNPCC, LCFS2, hMSH2, HNPCC1, MMRCS2

Protein Name: DNA mismatch repair protein Msh2

Poids moléculaire: 105kDa

ID gène: 4436

NCBI Accession: NP_000242

UniProt: P43246

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response