Renin anticorps (C-Term)

N° du produit ABIN2776795

Détail du produit anti-Renin anticorps

Antigène: Renin (REN)

Épitope: C-Term

Reactivité: Humain, Rat, Souris, Chien, Mouton, Boeuf (Vache), Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Renin est non-conjugé

Application: Western Blotting (WB)

Séquence: YSSKKLCTLA IHAMDIPPPT GPTWALGATF IRKFYTEFDR RNNRIGFALA

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against REN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human REN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 406 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Renin (ABIN2776795)

Kumai, Bernier, Perry: "Angiotensin-II promotes Na+ uptake in larval zebrafish, Danio rerio, in acidic and ion-poor water." dans: The Journal of endocrinology, Vol. 220, Issue 3, pp. 195-205, (2014) (PubMed).

Détails sur Renin

Antigène: Renin (REN)

Autre désignation: REN (REN Produits)

Synonymes: anticorps HNFJ2, anticorps RATRENAA, anticorps RENAA, anticorps Ren1, anticorps D19352, anticorps Ren, anticorps Ren-1, anticorps Ren-A, anticorps Ren1c, anticorps Ren1d, anticorps Rn-1, anticorps Rnr, anticorps renin, anticorps renin 1 structural, anticorps REN, anticorps Ren, anticorps Ren1, anticorps ren

Sujet: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Mutations in this gene have been shown to cause familial hyperproreninemia.Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
Alias Symbols: FLJ10761, HNFJ2
Protein Interaction Partner: AGT, ATP6AP2, KCTD15, PCSK5, RENBP, PCSK1, M6PR, CTSB,
Protein Size: 406

Poids moléculaire: 45 kDa

ID gène: 5972

NCBI Accession: NM_000537, NP_000528

UniProt: P00797

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour