Klotho anticorps (Middle Region)

N° du produit ABIN2776875

Détail du produit anti-Klotho anticorps

Antigène: Klotho (KL)

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Lapin, Cheval, Boeuf (Vache), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Klotho est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: HAQNGKISIA LQADWIEPAC PFSQKDKEVA ERVLEFDIGW LAEPIFGSGD

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against KL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human KL

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1012 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Klotho (ABIN2776875)

Ritter, Zhang, Delmez, Finch, Slatopolsky: "Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats." dans: Kidney international, Vol. 87, Issue 6, pp. 1141-52, (2016) (PubMed).

Détails sur Klotho

Antigène: Klotho (KL)

Autre désignation: KL (KL Produits)

Sujet: KL is a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: -
Protein Interaction Partner: IGF1R,
Protein Size: 1012

Poids moléculaire: 116 kDa

ID gène: 9365

NCBI Accession: NM_004795, NP_004786

UniProt: Q9UEF7

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding