CD40 anticorps (N-Term)

N° du produit ABIN2777068

Cet anticorps Lapin Polyclonal détecte spécifiquement CD40 dans WB. Il présente une réactivité envers Humain, Lapin, Cheval et Cobaye.

Aperçu rapide pour CD40 anticorps (N-Term) (ABIN2777068)

Antigène: CD40

Reactivité: Humain, Lapin, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CD40 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CD40 anticorps

Épitope: N-Term

Séquence: SQCCSLCQPG QKLVSDCTEF TETECLPCGE SEFLDTWNRE THCHQHKYCD

Homologie: Guinea Pig: 91%, Horse: 83%, Human: 100%, Rabbit: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CD40. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CD40

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 203 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CD40

Antigène: CD40

Autre désignation: CD40

Sujet: CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3).The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: Bp50, CDW40, MGC9013, TNFRSF5, p50
Protein Interaction Partner: TRAF2, TRAF3, PIK3R1, CD40LG, BAG3, Otud7b, Birc3, IL4R, TRAF6, TRAF5, TRAF3IP2, MAP3K8, TRAF4, TRAF1, PIK3CA, CBL, BIRC2, CDC40, TANK, HSPA4, NSMAF, XRCC5, HSPA8, TDP2, RIPK2, CAV1, JAK3, XRCC6, MS4A1, SUMO1, SLC30A7, RNF219, UGGT1, ERP44, NCOA6, USP15,
Protein Size: 203

Poids moléculaire: 20 kDa

ID gène: 958

NCBI Accession: NM_152854, NP_690593

UniProt: P25942

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints