SOX2 anticorps (N-Term)

N° du produit ABIN2777428

L’anticorps Lapin Polyclonal anti-SOX2 a été validé pour WB et IHC. Il convient pour détecter SOX2 dans des échantillons de Humain, Souris, Rat, Chévre, Boeuf (Vache), Porc, Mouton, Poisson zèbre (Danio rerio), Cheval, Lapin et Chien. Il y a 2+ publications disponibles.

Aperçu rapide pour SOX2 anticorps (N-Term) (ABIN2777428)

Antigène: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Reactivité: Humain, Souris, Rat, Chévre, Boeuf (Vache), Porc, Mouton, Poisson zèbre (Danio rerio), Cheval, Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SOX2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SOX2 anticorps

Épitope: N-Term

Séquence: MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 91%

Attributs du produit: This is a rabbit polyclonal antibody against SOX2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SOX2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 317 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SOX2 (ABIN2777428)

Lenz, Konecna, Tichy, Machacova, Fiala, Hurnik, Kyllar: "Unique expression patterns of the embryonal stem cell marker SOX2 and hormone receptors suggest the existence of a subpopulation of epithelial stem/progenitor cells in porcine and bovine endometrium." dans: Veterinary medicine and science, (2022) (PubMed).

Perry, Thomas, Henry: "Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells." dans: Developmental biology, Vol. 374, Issue 2, pp. 281-94, (2013) (PubMed).

Détails sur SOX2

Antigène: SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))

Autre désignation: SOX2

Sujet: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in this gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation. This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ANOP3, MCOPS3, MGC2413
Protein Interaction Partner: SUMO1, DMAP1, TBX2, SETD7, FAM21A, FZR1, MMS19, MRPS35, ZNF462, LSM2, CCAR2, MIER1, ZDBF2, CHD8, EP400, TSHZ3, RANBP10, ZNF687, XPO5, INTS2, MTA3, CORO1B, CASC5, MRPS22, KCMF1, MEPCE, TRERF1, INTS9, PARVA, SCYL2, CHD7, ZCCHC8, SOX6, BRIX1, SAMD4B, GID8, C
Protein Size: 317

Poids moléculaire: 34 kDa

ID gène: 6657

NCBI Accession: NM_003106, NP_003097

UniProt: P48431

Pathways: Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis