FOXA2 anticorps (Middle Region)

N° du produit ABIN2777512

Il existe 3+ publications pour ce produit. L’anticorps anti-FOXA2 Polyclonal Lapin est utilisé pour la détection de FOXA2 dans des échantillons de Humain, Rat, Souris, Chien, Lapin, Cheval et Porc. Il a été validé pour WB.

Aperçu rapide pour FOXA2 anticorps (Middle Region) (ABIN2777512)

Antigène: FOXA2 (Forkhead Box A2 (FOXA2))

Reactivité: Humain, Rat, Souris, Chien, Lapin, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXA2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FOXA2 anticorps

Épitope: Middle Region

Fonction: FOXA2 Antibody - middle region

Séquence: ASQAQLGEAA GPASETPAGT ESPHSSASPC QEHKRGGLGE LKGTPAAALS

Homologie: Dog: 100%, Horse: 100%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 77%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against FOXA2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human FOXA2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31944-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-FOXA2 (ABIN2777512)

Kallas, Pook, Trei, Maimets: "SOX2 Is Regulated Differently from NANOG and OCT4 in Human Embryonic Stem Cells during Early Differentiation Initiated with Sodium Butyrate." dans: Stem cells international, Vol. 2014, pp. 298163, (2014) (PubMed).

Menga, Infantino, Iacobazzi, Convertini, Palmieri, Iacobazzi: "Insight into mechanism of in vitro insulin secretion increase induced by antipsychotic clozapine: role of FOXA1 and mitochondrial citrate carrier." dans: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 23, Issue 8, pp. 978-87, (2013) (PubMed).

Richards, Park, Chen, Gibson, Peter Di, Pardo, Watkins, Choi, Selman, Pilewski, Kaminski, Zhang: "Allele-specific transactivation of matrix metalloproteinase 7 by FOXA2 and correlation with plasma levels in idiopathic pulmonary fibrosis." dans: American journal of physiology. Lung cellular and molecular physiology, Vol. 302, Issue 8, pp. L746-54, (2012) (PubMed).

Détails sur FOXA2

Antigène: FOXA2 (Forkhead Box A2 (FOXA2))

Autre désignation: FOXA2

Sujet:

Background Information: FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young.This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene. This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.

Gene Name: Forkhead box A2

Alternative Symbols: HNF3B, TCF3B, HNF-3-beta

Protein Name: Hepatocyte nuclear factor 3-beta

Poids moléculaire: 48kDa

ID gène: 3170

NCBI Accession: NP_068556

UniProt: Q9Y261

Pathways: Dopaminergic Neurogenesis, Regulation of Carbohydrate Metabolic Process