HNF4A anticorps (N-Term)

N° du produit ABIN2777514

Il existe 4+ publications pour ce produit. L’anticorps anti-HNF4A Polyclonal Lapin est utilisé pour la détection de HNF4A dans des échantillons de Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Mouton et Poisson zèbre (Danio rerio). Il a été validé pour WB.

Aperçu rapide pour HNF4A anticorps (N-Term) (ABIN2777514)

Antigène: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HNF4A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-HNF4A anticorps

Épitope: N-Term

Fonction: HNF4A Antibody - N-terminal region

Séquence: MRLSKTLVDM DMADYSAALD PAYTTLEFEN VQVLTMGNDT SPSEGTNLNA

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against HNF4A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human HNF4A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP31946-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HNF4A (ABIN2777514)

Faure, Schmidt, Watt, Schwalie, Wilson, Xu, Ramsay, Odom, Flicek: "Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules." dans: Genome research, Vol. 22, Issue 11, pp. 2163-75, (2012) (PubMed).

Schmidt, Wilson, Ballester, Schwalie, Brown, Marshall, Kutter, Watt, Martinez-Jimenez, Mackay, Talianidis, Flicek, Odom: "Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding." dans: Science (New York, N.Y.), Vol. 328, Issue 5981, pp. 1036-40, (2010) (PubMed).

Schmidt, Schwalie, Ross-Innes, Hurtado, Brown, Carroll, Flicek, Odom: "A CTCF-independent role for cohesin in tissue-specific transcription." dans: Genome research, Vol. 20, Issue 5, pp. 578-88, (2010) (PubMed).

Weedon, Owen, Shields, Hitman, Walker, McCarthy, Love-Gregory, Permutt, Hattersley, Frayling: "Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population." dans: Diabetes, Vol. 53, Issue 11, pp. 3002-6, (2004) (PubMed).

Détails sur HNF4A

Antigène: HNF4A (Hepatocyte Nuclear Factor 4, alpha (HNF4A))

Autre désignation: HNF4A

Sujet:

Background Information: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

Gene Name: Hepatocyte nuclear factor 4, alpha

Alternative Symbols: TCF, HNF4, MODY, FRTS4, MODY1, NR2A1, TCF14, HNF4a7, HNF4a8, HNF4a9, NR2A21, HNF4alpha

Protein Name: Hepatocyte nuclear factor 4-alpha

Poids moléculaire: 53kDa

ID gène: 3172

NCBI Accession: NP_000448

UniProt: P41235

Pathways: AMPK Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process