DUSP12 anticorps (N-Term)

N° du produit ABIN2777632

Cet anticorps anti-DUSP12 est un anticorps Lapin Polyclonal détectant DUSP12 dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin et Cobaye.

Aperçu rapide pour DUSP12 anticorps (N-Term) (ABIN2777632)

Antigène: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DUSP12 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DUSP12 anticorps

Épitope: N-Term

Séquence: VEDLWRLFVP ALDKPETDLL SHLDRCVAFI GQARAEGRAV LVHCHAGVSR

Homologie: Cow: 100%, Dog: 86%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against DUSP12. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DUSP12

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 340 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur DUSP12

Antigène: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Autre désignation: DUSP12

Sujet: DUSP12 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.
Alias Symbols: DUSP1, YVH1
Protein Interaction Partner: PPP2R3B, HSPB8, RABAC1, CALCOCO2, USO1, EIF5, CCNH, UBC, APP, NR1H2, KIAA1377, MBD6, PTN,
Protein Size: 340

Poids moléculaire: 38 kDa

ID gène: 11266

NCBI Accession: NM_007240, NP_009171

UniProt: Q9UNI6

Pathways: Regulation of Carbohydrate Metabolic Process