KDM4C anticorps (Middle Region)

N° du produit ABIN2777688

Cité dans 1 publication. Cet anticorps anti-KDM4C Polyclonal Lapin (ABIN2777688) détecte spécifiquement KDM4C dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye et Porc.

Aperçu rapide pour KDM4C anticorps (Middle Region) (ABIN2777688)

Antigène: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM4C est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-KDM4C anticorps

Épitope: Middle Region

Fonction: JMJD2C Antibody - C-terminal region

Séquence: CLCNLRGGAL KQTKNNKWAH VMCAVAVPEV RFTNVPERTQ IDVGRIPLQR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against JMJD2C. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human JMJD2C

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32974-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-KDM4C (ABIN2777688)

Lu, Ward, Kapoor, Rohle, Turcan, Abdel-Wahab, Edwards, Khanin, Figueroa, Melnick, Wellen, ORourke, Berger, Chan, Levine, Mellinghoff, Thompson: "IDH mutation impairs histone demethylation and results in a block to cell differentiation." dans: Nature, Vol. 483, Issue 7390, pp. 474-8, (2012) (PubMed).

Détails sur KDM4C

Antigène: KDM4C (Lysine (K)-Specific Demethylase 4C (KDM4C))

Autre désignation: JMJD2C

Sujet:

Background Information: JMJD2C is a member of the Jumonji domain 2 (JMJD2) family. It contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.

Gene Name: Lysine (K)-specific demethylase 4C

Alternative Symbols: GASC1, JHDM3C, JMJD2C, TDRD14C

Protein Name: Lysine-specific demethylase 4C Ensembl ENSP00000445427

Poids moléculaire: 92 kDa

ID gène: 23081

NCBI Accession: NP_001140167

UniProt: F5H347

Pathways: Nuclear Hormone Receptor Binding, L'effet Warburg