PCCA anticorps (N-Term)

N° du produit ABIN2777736

Cité dans 1 publication. Cet anticorps anti-PCCA Polyclonal Lapin (ABIN2777736) détecte spécifiquement PCCA dans WB et IHC. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio), Chien, Porc et Lapin.

Aperçu rapide pour PCCA anticorps (N-Term) (ABIN2777736)

Antigène: PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio), Chien, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PCCA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-PCCA anticorps

Épitope: N-Term

Fonction: PCCA Antibody - N-terminal region

Séquence: LYYSRQCLMV SRNLGSVGYD PNEKTFDKIL VANRGEIACR VIRTCKKMGI

Homologie: Cow: 86%, Dog: 86%, Horse: 83%, Human: 100%, Mouse: 77%, Pig: 86%, Rabbit: 86%, Rat: 86%, Zebrafish: 75%

Attributs du produit: This is a rabbit polyclonal antibody against PCCA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PCCA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8109054

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PCCA (ABIN2777736)

Rincón, Aguado, Desviat, Sánchez-Alcudia, Ugarte, Pérez: "Propionic and methylmalonic acidemia: antisense therapeutics for intronic variations causing aberrantly spliced messenger RNA." dans: American journal of human genetics, Vol. 81, Issue 6, pp. 1262-70, (2011) (PubMed).

Détails sur PCCA

Antigène: PCCA (Propionyl CoA Carboxylase, alpha Polypeptide (PCCA))

Autre désignation: PCCA

Sujet:

Background Information: PCCA is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA is the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia.The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: Propionyl CoA carboxylase, alpha polypeptide

Alternative Symbols: -

Protein Name: Propionyl-CoA carboxylase alpha chain, mitochondrial

Poids moléculaire: 75kDa

ID gène: 5095

NCBI Accession: NP_000273

UniProt: Q8WXQ7

Pathways: Monocarboxylic Acid Catabolic Process