Diazepam Binding Inhibitor anticorps (N-Term)

N° du produit ABIN2777771

Cet anticorps Lapin Polyclonal détecte spécifiquement Diazepam Binding Inhibitor dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye et Lapin.

Aperçu rapide pour Diazepam Binding Inhibitor anticorps (N-Term) (ABIN2777771)

Antigène: Diazepam Binding Inhibitor (DBI)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Diazepam Binding Inhibitor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Diazepam Binding Inhibitor anticorps

Épitope: N-Term

Fonction: DBI Antibody - N-terminal region

Séquence: MSQAEFEKAA EEVRHLKTKP SDEEMLFIYG HYKQATVGDI NTERPGMLDF

Homologie: Cow: 86%, Dog: 79%, Guinea Pig: 92%, Human: 100%, Mouse: 85%, Rabbit: 86%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against DBI. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DBI

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP33135-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Diazepam Binding Inhibitor

Antigène: Diazepam Binding Inhibitor (DBI)

Autre désignation: DBI

Sujet:

Background Information: DBI is diazepam binding inhibitor. The protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. DBI is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene.

Gene Name: Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)

Alternative Symbols: EP, ACBP, ACBD1, CCK-RP

Protein Name: Acyl-CoA-binding protein

Poids moléculaire: 10kDa

ID gène: 1622

NCBI Accession: NP_001073331

UniProt: P07108